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EMA Reference Guide

EMA Regulatory Timeline & Calendar

Track CHMP meeting schedules, approval timelines, and key regulatory deadlines for the European Medicines Agency. Essential planning tool for European submissions.

2025 CHMP Meeting Calendar

Committee for Medicinal Products for Human Use - Official Meeting Dates

January

13-16, 27-30

February

10-13, 24-27

March

10-13, 24-27

April

7-10, 28-May 1

May

12-15, 26-29

June

9-12, 23-26

July

14-17, 28-31

August

No meeting (summer break)

September

8-11, 22-25

October

13-16, 27-30

November

10-13, 24-27

December

8-11

Note: CHMP opinions are typically published 2-3 weeks after each meeting. Agendas and highlights are available on the EMA website following each session.

Centralized Procedure: Marketing Authorization Timeline

Standard timeline from MAA submission to European Commission decision (approximately 210 days + 67 days)

Day 0

Submission

Marketing Authorization Application (MAA) submitted via centralized or national procedure

Day 1-14

Validation

EMA validates application completeness. Requests missing information if needed.

Day 15-120

Initial Assessment

Rapporteur and Co-Rapporteur prepare assessment reports. CHMP reviews.

Day 121-150

Questions to Applicant

List of questions sent to applicant regarding deficiencies or clarifications needed

Day 151-180

Applicant Response

Applicant submits responses to questions (clock stops during this period)

Day 181-210

Assessment of Response

Rapporteurs assess responses. May request additional information or oral explanation.

Day 210

CHMP Opinion

CHMP adopts final opinion (positive or negative) on marketing authorization

Day 211-277 (67 days)

European Commission Decision

European Commission adopts final legally binding decision based on CHMP opinion

Important Notes:

  • • Clock stops during applicant response period (Day 151-180)
  • • Additional clock stops may occur if oral explanations or re-assessments are needed
  • • Accelerated assessment (150 days instead of 210) available for products of major public health interest
  • • Post-approval conditions may be imposed requiring additional studies or data

Key EMA Regulatory Deadlines & Events

CHMP Opinions
High

Published monthly after CHMP meetings

Frequency: ~2-3 weeks after meeting

Impact: High - Indicates upcoming marketing authorizations

Guideline Consultations
Medium

Draft guidelines open for stakeholder comments

Frequency: Ongoing - check quarterly

Impact: Medium - Shape future regulatory requirements

Annual Work Programme
High

EMA publishes priorities and planned activities

Frequency: Q4 annually (typically November)

Impact: High - Strategic planning for next year

Scientific Advice Deadlines
High for applicants

Applications for scientific advice meetings

Frequency: Monthly - typically 2 months before desired meeting

Impact: High for applicants

Referral Decisions
High

Safety reviews and harmonization procedures

Frequency: As needed - check monthly

Impact: High - May affect marketed products

Therapeutic Area Guidance Updates

Typical timing for major guideline updates by therapeutic area (subject to change)

Oncology

Priority: High

Typical Updates: Q1, Q3 typically

Vaccines

Priority: High

Typical Updates: Q2, Q4 typically

Advanced Therapy Medicinal Products (ATMPs)

Priority: High

Typical Updates: Q2, Q3 typically

Rare Diseases

Priority: Medium

Typical Updates: Ongoing

Paediatrics

Priority: Medium

Typical Updates: Q1, Q3 typically

Biosimilars

Priority: Medium

Typical Updates: Q4 typically

Strategic Planning Tips

  • Time submissions strategically:

    Avoid August (CHMP summer break) and December (reduced staffing) if possible

  • Monitor CHMP agendas in advance:

    Agendas published before meetings—track competitor products and relevant discussions

  • Plan for clock-stop responses:

    Build 3-6 month buffer into project timelines for questions and responses

  • Subscribe to EMA stakeholder alerts:

    Or use RegulatoryAlerts to automatically track all EMA updates filtered to your areas

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